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Marrow Cellution™

Bone Marrow derived Stem Cells

A breaktrough marrow aspiration system offering high concentrations of stem cells ready to use in an office setting in less than 10 minutes

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What is Marrow Cellution™?

Maximize Cell Yield
Percutaneous Bone Graft Harvesting

Stem cells from bone marrow

The Marrow Cellution™ System maximizes stem and progenitor cell recovery and minimizes excess blood collection. Thus, it prevents the subsequent need for additional manipulation procedures such as centrifugation and/or chemical separation which usually require oversight by national regulatory authorities.


"Regenerative medicine has the potential to revolutionize healthcare by providing new treatments for diseases and injuries that are currently untreatable or have limited treatment options."

International Society for Stem Cell Research (ISSCR)

Designed and Manufactured for Stem Cell harvesting from Bone Marrow


  • Reduces Excess Blood Collection

  • Closed-end Aspiration Design

  • Cannula via Sheath Technology

  • Lateral vs. Distal Collection


  • Never Leaves Sterile Field

  • Higher CFU-f Counts per mL

  • Autologous Bone Graft Collection

  • Additional Steps Not Required


  • Minimally Invasive

  • Low Volume—High Yield & Quality

  • Single Puncture—Multiple Aspirations

  • Regulatory Compliant

Marrow Cellution provides substantial savings in time, effort and expense. It reduces patient trauma, morbidity and risk of infection.

Bone Marrow Aspiration

The regenerative qualities of bone marrow have been used for decades and are considered the gold standard for stem cell harvesting. However, after the first 1-2 mL of bone marrow aspirate from a traditional needle, the number of total nucleated cells (TNC) in the aspirate drops dramatically due to the lower viscosity of blood and the design of the needle, which operates most optimally for small biopsy volume. After aspirating the first 1-2 mL of bone marrow, peripheral blood will preferentially fill the vacated space, limiting the additional harvest of key stem and progenitor cells.

The Marrow Cellution™ Bone Marrow Aspiration System overcomes this issue. It allows the user to aspirate in a measured and controlled manner over a large geography inside the marrow space, while restricting peripheral blood infiltration.

Traditional Trocars collect additional excess peripheral blood, diminishing cellular yield; thereby requiring additional manipulation steps to achieve the cellular demand necessary for most clinical indications.

Trokar aspiration

Marrow Cellution™ harvests high quality stem and progenitor cells from various levels within the marrow space, while limiting peripheral blood infiltration. The system never leaves the sterile field and does not require further manipulation.

Marrow cellution stem cell aspiration

Functional Design

High Quality Marrow Aspiration — Minimal Manipulation
The Marrow Cellution™ Bone Marrow Aspiration System is intended for use for aspiration of bone marrow or autologous blood. It allows the user to aspirate in a measured and controlled manner over a large geography inside the marrow space.

Marrow Cellution™ is available in both 11G and 13G and includes an introducer needle, blunt stylet, aspiration cannula and 10 mL syringe. The technology is available in multiple lengths and is designed for use in the Iliac Crest, Pedicle, Calcaneus or Tibia.

What makes the difference?
Every Marrow Cellution™ System includes two important unique features that are not capable with a traditional needle:

  • A closed-tip aspiration cannula that only allows aspiration through the side holes of the cannula, blocking the channel created by the needle tip. This feature avoids excessive peripheral blood infiltration.

  • A mechanical means for measured and controlled retraction of the aspiration cannula to collect bone marrow aspirate from multiple geographies inside the medullary space with a single puncture.

Stem cells from bone marrow kit

Bone Marrow Aspiration with the Marrow Cellution™ System

Stem cells process steps

Some Science: CFU-F Counts

When a sample of bone marrow or other tissues is cultured in vitro, the CFU-F count can be used as a measure of the number of mesenchymal stem cells present in the sample. This is because MSCs have the ability to form colonies of fibroblast-like cells, which are visible under a microscope as a cluster of cells.

Therefore, there is a positive correlation between CFU-F count and mesenchymal stem cells. A higher CFU-F count in a sample indicates a higher number of MSCs in that sample.

Marrow cellution stem cells versus others

(1) n=5; Scarpone MA, et al. Marrow Cellution Bone Marrow Aspiration System and Related Concentrations of Stem and Progenitor Cells. White Paper 2015.
(2) n=30; Scarpone MA, et al. Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation. J Transl Med (2019) 17:10.
(3) n=27; Harrell DB, Purita JR. Novel Technology to Increase Concentrations of Stem and Progenitor Cells from Marrow Aspiration. White Paper 2016.
(4) Hegde V, et al. A prospective comparison of three approved systems for autologous bone marrow concentration demonstrated non-equivalency in progenitor cell number and concentration. J Orthop Trauma. 2014 Oct;28(10):591-8.
(5) McLain R, et al. Aspiration of Osteoprogenitor Cells for Augmenting Spinal Fusion: Comparison of Progenitor Cell Concentrations From the Vertebral Body and Iliac Crest. J Bone Joint Surg Am. 2005 Dec; 87(12): 2655–2661.


Combining High Quality Bone Marrow Aspirate and Percutaneously Harvested Cancellous Bone Autograft
The high cellular composition of Marrow Cellution™ aspirate combined with percutaneously harvested bone cores delivers autograft without the associated morbidity.

Stem cells and bone dowel
Stem cells and bone dowel



  • Gold standard graft material

Delivers graft material with osteoconductive, osteoinductive & osteogenic properties.

  • Minimally invasive technique

Uses a 8 Gauge Trephine Needle for bone core extraction (bone core volume calculation).

  • Allows highly active combination graft

Graft material may be combined with autologous, allogenic, xenogenic or synthetic bone chips hydrated with high cellular marrow aspirate.

  • Less morbidity at the donor site

Reduces donor site morbidity associated with standard harvesting techniques.

Bone Dowel Harvesting with the Marrow Cellution™ System

Stem cells and bone dowel harvesting

Paul D. Tortland, D.O., FAOASM, RMSK
Associate Clinical Professor of Medicine, University of Connecticut School of Medicine

"Hands down, the best method is the new Marrow Cellution needle. It’s a game changer. Far easier to use, only one insertion point through the PSIS (rather than multiple entry sites through the ilium), and a MUCH better stem cell yield than the traditional Jamshidi needle approach."

Download the Marrow Cellution™ System brochure

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