What is Bone-Graft Surgery?
Also known as: Xenohybrid bone graft (SmartBone® ORTHO), Bone substitute, Bone void filler, Synthetic-augmented bovine bone graft
SmartBone® ORTHO is a xenohybrid biomimetic bone graft engineered to combine the trabecular architecture of native bone with the toughness and biocompatibility of synthetic polymer reinforcement. The graft is built on a decellularised, deproteinised bovine mineral matrix coated with poly(L-lactide-co-ε-caprolactone) (PLCL) and supplemented with RGD-containing collagen fragments. The structure is osteoconductive, accepts cell ingrowth and vascularisation, and is gradually replaced by host bone over months while the polymer degrades.
The graft is used for hand and wrist trauma reconstruction, post-oncology bone reconstruction, high tibial osteotomy, revision arthroplasty (acetabular and femoral bone stock restoration), long-bone non-union and pseudoarthrosis, and spinal fusion. Because SmartBone® ORTHO contains no human donor tissue and uses processed bovine matrix, the procedure avoids the donor-site morbidity of autograft and the supply and immunogenicity concerns of allograft. OrganoGEN is the exclusive Cyprus distributor of SmartBone® ORTHO for IBI Industrie Biomediche Insubri SA, Mezzovico-Vira, Switzerland.
📋 Procedure at a Glance
- Graft
- SmartBone® ORTHO (IBI Industrie Biomediche Insubri SA, Switzerland)
- Composition
- Decellularised bovine matrix + PLCL polymer + RGD-collagen fragments
- Tissue source
- Processed bovine matrix (no human donor, no autograft)
- Forms
- Block, wedge, rod, granules
- GESY
- Covered
Am I a candidate?
Good candidates
- Distal radial fractures with bone loss after reduction
- Tibial plateau fractures with depression or comminuted bone defect
- High tibial osteotomy (opening-wedge), particularly with osteotomy gap >10 mm
- Bone-tumor curettage cavities (benign or malignant, paediatric or adult)
- Acetabular or femoral bone stock loss in revision arthroplasty
- Long-bone non-union or pseudoarthrosis requiring osteoconductive scaffold
- Long-bone segmental defects requiring void filling
- Spinal fusion adjunct (cervical or lumbar)
- Patients seeking to avoid autograft donor-site morbidity
Patients in whom another option may be preferred
- Active local or systemic infection
- Severely compromised vascularity at the recipient site
- Patient-specific contraindications to bovine-derived materials
- Skeletally immature patients in load-bearing primary defects (per surgeon judgement)
GESY coverage & out-of-pocket cost
For Cyprus residents enrolled in GESY, bone-graft surgery using SmartBone® ORTHO is fully covered when performed by a participating surgeon at a GESY-contracted hospital. The cost of the graft is included in the hospital reimbursement, and patients are not billed separately for the implant.
For self-pay or international patients, OrganoGEN provides hospital quotations on request. Request a quote.
Devices used in this procedure
SmartBone® Synthetic Bone GraftBone Reconstruction · Synthetic Graft
Where to have Bone-Graft Surgery in Cyprus
OrganoGEN supplies GESY-contracted hospitals across the island. Contact us for the current list of participating surgeons in:
Talk to a surgeon in Cyprus
OrganoGEN can connect you with a participating GESY-contracted surgeon for a consultation.
This article was reviewed on 9 May 2026. Information is educational and not a substitute for individual surgical advice. Patient outcomes vary; please consult a qualified surgeon to discuss whether this procedure is right for you.
