What is PRGF (PRP) Injection?

Also known as: Plasma Rich in Growth Factors injection, PRP injection, autologous platelet-rich plasma, leukocyte-poor PRP, intra-articular platelet injection, intratendinous PRP, growth factor injection, regenerative orthobiologics, autologous platelet therapy

PRGF (Plasma Rich in Growth Factors) is the standardised, leukocyte-free autologous platelet protocol developed by BTI Biotechnology Institute (Vitoria-Gasteiz, Spain). Generic "PRP" varies in preparation, platelet concentration, leukocyte content, and activator. PRGF differs in protocol, characterisation, and regulatory file: a closed, single-step centrifugation that yields two plasma fractions (F1 at 1 to 1.5x platelet concentration, F2 at 2 to 3x and leukocyte-free), activated with calcium chloride immediately before infiltration.

In Cyprus, PRGF is administered using the Endoret® system, distributed exclusively by OrganoGEN. A small autologous blood draw is processed on-site, activated, and infiltrated at the target joint, tendon, or soft-tissue lesion. Typical clinic visit is under 60 minutes end-to-end. The technology has been used clinically since 1999, the first PRP-class biologic published for musculoskeletal indications.

Am I a candidate?

Good candidates

• Mild-to-moderate knee osteoarthritis (Kellgren-Lawrence grade 1 to 3)
• Mild-to-moderate hip or shoulder osteoarthritis
• Chronic tendinopathy (rotator cuff, lateral epicondyle, patellar, achilles, plantar fascia)
• Soft-tissue injury and post-surgical augmentation
• Patients seeking a non-surgical regenerative option, or seeking to delay arthroplasty

Patients in whom another option may be preferred

• Active local or systemic infection
• Active malignancy at or near the target site
• Severe haematological disorder or coagulopathy
• End-stage osteoarthritis (Kellgren-Lawrence 4) where joint replacement is the appropriate option
• Patient-specific contraindications to autologous blood handling

GESY coverage & out-of-pocket cost

This is a private-pay procedure. Endoret® (PRGF) sits in the regenerative tier in Cyprus and is not covered by GESY. GESY covers standard orthopaedic surgical procedures and conventional injectables. Autologous biologics are private-pay. OrganoGEN provides clinic quotations on request. Request a quote.

Devices used in this procedure

Endoret® PRGF - Plasma Rich in Growth FactorsRegenerative Medicine · Plasma Rich in Growth Factorschevron_right

Where to have PRGF (PRP) Injection in Cyprus

OrganoGEN supplies GESY-contracted hospitals across the island. Contact us for the current list of participating surgeons in: